Intermittent Hypoxia Therapy
Intermittent Hypoxia Therapy is a powerful therapeutic tool employed by Dr. Steenblock. What is the basis of IHT? Well, when the human body is exposed to a low oxygen environment it has to adapt in terms of producing the energy it needs with less available oxygen. This adaptive process enhances the efficiency of the body’s native respiratory, cardiovascular and oxygen utilization processes and systems.
Among the wondrous effects it has on the human body:
- Increases collateral circulation.
- Boosts the efficiency of the cell’s internal power-producers, the mitochondria.
- Increases the number of mitochondria inside cells.
- Bolsters a patient’s ability to handle stress as well as infections.
Dr. Steenblock often uses IHT to help mobilize a patient’s own stem cells prior to giving them a stem cell rich bone marrow treatment.
These websites will help flesh out the clinical benefits of IHT further:
Curious as to what IHT might do to help address your health needs? A stem cell-rich bone marrow treatment? You can find out for free by calling Dr. Steenblock’s Clinic at 1-800-300-1063 and asking for a “free stem cell consultation.”
A sampling of the many papers published on Hypoxia and its effects on animal & human physiology:
J Appl Physiol 1992 Jun;72(6):2238-43 Brain adaptation to chronic hypobaric hypoxia in rats. LaManna JC, Vendel LM, Farrell RM [Abstract]
N Engl J Med 1977 Mar 17;296(11):581-5 Reduction in mortality from coronary heart disease in men residing at high altitude. Mortimer EA Jr, Monson RR, MacMahon B [Abstract]
Brain Res 1994 May 2;644(2):297-304. Hypoxia protects against the neurotoxicity of kainic acid. Pohle W, Rauca C [Abstract]
Eur J Appl Physiol. 2009 Jan 6.
Effect of two durations of short-term intermittent hypoxia on ventilatory chemosensitivity in humans. Katayama K, Ishida K, Iwasaki KI, Miyamura M. [Abstract]
Sports Med. 2009;39(2):107-127. Sea-Level Exercise Performance Following Adaptation to Hypoxia: A Meta-Analysis. Bonetti DL, Hopkins WG.[Abstract]
Respir Physiol Neurobiol. 2008 Nov 1. Intermittent hypoxia increases exercise tolerance in patients at risk for or with mild COPD. Burtscher M, Haider T, Domej W, Linser T, Gatterer H, Faulhaber M, Pocecco E, Ehrenburg I, Tkatchuk E, Koch R, Bernardi L. [Abstract]
Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1613-22. Epub 2008 Sep 3. Cerebral hypoperfusion during hypoxic exercise following two different hypoxic exposures: independence from changes in dynamic autoregulation and reactivity. Ainslie PN, Hamlin M, Hellemans J, Rasmussen P, Ogoh S. [Abstract]
J Perinat Med. 2008;36(2):161-7. Prenatal hypoxia preconditioning improves hypoxic ventilatory response and reduces mortality in neonatal rats. Wang R, Xu F, Liu J. [Abstract]
Bull Exp Biol Med. 2008 Jun;145(6):661-4.Effects of intermittent hypoxic training on orthostatic reactions of the cardiorespiratory system.Donina ZhA, Lavrova IN, Tikhonov MA. [Abstract]
Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):27-32. Epub 2008 May 17. Protection of the right ventricle from ischemia and reperfusion by preceding hypoxia. Wasserfuhr D, Cetin SM, Yang J, Freitag P, Frede S, Jakob H, Massoudy P. [Abstract]
Eur J Appl Physiol. 2008 Nov 19. Effect of intermittent hypoxic training on HIF gene expression in human skeletal muscle and leukocytes.Mounier R, Pialoux V, Roels B, Thomas C, Millet G, Mercier J, Coudert J, Fellmann N, Clottes E. [Abstract]
Exp Physiol. 2008 Dec 12. Intermittent hypoxia and respiratory plasticity in animals and humans; Does exposure to intermittent hypoxia promote or mitigate sleep apnea?
Mateika JH, Narwani G. [Abstract]
Exp Biol Med (Maywood). 2008 Jun;233(6):627-50. Epub 2008 Apr 11. Review.
Intermittent hypoxia: cause of or therapy for systemic hypertension?. Serebrovskaya TV, Manukhina EB, Smith ML, Downey HF, Mallet RT. [Abstract]
Exp Biol Med (Maywood). 2006 Apr;231(4):343-65.
Role of nitric oxide in cardiovascular adaptation to intermittent hypoxia.
Manukhina EB, Downey HF, Mallet RT. [Abstract]
Essays Biochem. 2007;43:91-104. Cellular mechanisms associated with intermittent hypoxia.
Nanduri J, Nanduri RP [Abstract]
Med Sci Sports Exerc. 2007 Sep;39(9):1600-9. Nonhematological mechanisms of improved sea-level performance after hypoxic exposure. Gore CJ, Clark SA, Saunders PU.
[Abstract]
Effects of simulated altitude (normobaric hypoxia) on cardiorespiratory parameters and circulating endothelial precursors in healthy subjects. Ciulla MM, Cortiana M, Silvestris I, Matteucci E, Ridolfi E, Giofrè F, Zanardelli M, Paliotti R, Cortelezzi A, Pierini A, Magrini F, Desiderio MA. Respir Res. 2007 Aug 8;8:58. [Abstract]
J Mol Cell Cardiol. 2006 Jan;40(1):96-106. Epub 2005 Nov 8. Intermittent high altitude hypoxia inhibits opening of mitochondrial permeability transition pores against reperfusion injury. Zhu WZ, Xie Y, Chen L, Yang HT, Zhou ZN. [Abstract]
Fiziol Zh. 2005;51(4):3-12. [Effect of the hypoxia training on the sensitivity of phenylarsineoxide-induced mitochondrial permeability transition pore opening in the rat heart] Vavilova HL, Serebrovs’ka TV, Rudyk OV, Bielikova MV, Koliesnikova IeE, Kukoba TV, Sahach VF.[Abstract]
High Alt Med Biol. 2005 Fall;6(3):215-25. Effects of intermittent hypoxia on heart rate variability during rest and exercise. Povea C, Schmitt L, Brugniaux J, Nicolet G, Richalet JP, Fouillot JP. [Abstract]
Brain Res. 2005 Sep 7;1055(1-2):1-6. Neurogenesis in the adult rat brain after intermittent hypoxia. Zhu LL, Zhao T, Li HS, Zhao H, Wu LY, Ding AS, Fan WH, Fan M. [Abstract]
J Appl Physiol. 2005 Sep;99(3):1064-9. Epub 2005 May 5. Acute intermittent hypoxia improves rat myocardium tolerance to ischemia. Beguin PC, Joyeux-Faure M, Godin-Ribuot D, Levy P, Ribuot C. [Abstract]
Clin Exp Pharmacol Physiol. 2005 May-Jun;32(5-6):447-9.
Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes. Prabhakar NR, Peng YJ, Jacono FJ, Kumar GK, Dick TE. [Abstract]
High Alt Med Biol. 2005 Spring;6(1):50-9. Effect of a repeated series of intermittent hypoxic exposures on ventilatory response in humans.Katayama K, Fujita H, Sato K, Ishida K, Iwasaki K, Miyamura M. [Abstract]
Respir Physiol Neurobiol. 2005 Mar;146(1):55-65. Changes in ventilatory responses to hypercapnia and hypoxia after intermittent hypoxia in humans. Katayama K, Sato K, Matsuo H, Hotta N, Sun Z, Ishida K, Iwasaki K, Miyamura M. [Abstract]
High Alt Med Biol. 2005 Fall;6(3):215-25. Effects of Intermittent Hypoxia on Heart Rate Variability during Rest and Exercise. Povea C, Schmitt L, Brugniaux J, Nicolet G, Richalet JP, Fouillot JP. [Abstract]
Eur Respir J. 2005 Jan;25(1):173-80. Effects of intermittent hypoxia on pulmonary haemodynamics: animal models versus studies in humans.Zielinski J.
[Abstract]
J Physiol. 2005 Sep 1;567(Pt 2):689-99. Epub 2005 Jun 23. Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia. Foster GE, McKenzie DC, Milsom WK, Sheel AW. [Abstract]
Auton Neurosci. 2005 Aug 31;121(1-2):87-93. Effects of intermittent hypoxia on sympathetic activity and blood pressure in humans.Leuenberger UA, Brubaker D, Quraishi S, Hogeman CS, Imadojemu VA, Gray KS. [Abstract]
High Alt Med Biol. 2005 Fall;6(3):215-25. Effects of Intermittent Hypoxia on Heart Rate Variability during Rest and Exercise. Povea C, Schmitt L, Brugniaux J, Nicolet G, Richalet JP, Fouillot JP. [Abstract]
Acta Pharmacol Sin. 2005 Mar;26(3):315-22. Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury. Ding HL, Zhu HF, Dong JW, Zhu WZ, Yang WW, Yang HT, Zhou ZN. [Abstract]
High Alt Med Biol. 2003 Fall;4(3):291-304. Intermittent hypoxia improves endurance performance and submaximal exercise efficiency.Katayama K, Matsuo H, Ishida K, Mori S, Miyamura M. [Abstract]
High Alt Med Biol. 2003 Spring;4(1):81-91. Short-term altitude mountain living improves glycemic control. Lee WC, Chen JJ, Ho HY, Hou CW, Liang MP, Shen YW, Kuo CH. [Abstract]
Ross Fiziol Zh Im I M Sechenova. 2003 Nov;89(11):1370-9. [Mechanisms of human adaptation to hypoxia] Baranova TI, Kovalenko RI, Molchanov AA, Sviridenko MV, Ianvareva IN, Zhekalov AN. [Abstract]
Exp Physiol. 2003 Jan;88(1):109-19. Response of skeletal muscle mitochondria to hypoxia. Hoppeler H, Vogt M, Weibel ER, Flück M. [Abstract]
Ross Fiziol Zh Im I M Sechenova. 2003 Nov;89(11):1370-9. [Mechanisms of human adaptation to hypoxia] Baranova TI, Kovalenko RI, Molchanov AA, Sviridenko MV, Ianvareva IN, Zhekalov AN.[Abstract]
High Alt Med Biol. 2003 Winter;4(4):455-63. Effects of intermittent exposure to high altitude on pulmonary hemodynamics: a prospective study. Sarybaev AS, Palasiewicz G, Usupbaeva DA, Plywaczewski R, Maripov AM, Sydykov AS, Mirrakhimov MM, Le Roux H, Kadyrov T, Zielinski J. [Abstract]
Clin Exp Pharmacol Physiol. 2003 Sep;30(9):659-64. Intermittent hypobaric hypoxia increases the ability of neutrophils to generate superoxide anion in humans. Hitomi Y, Miyamura M, Mori S, Suzuki K, Kizaki T, Itoh C, Murakami K, Haga S, Ohno H. [Abstract]
Life Sci. 2003 Jul 25;73(10):1275-87. ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury.
Zhu HF, Dong JW, Zhu WZ, Ding HL, Zhou ZN. [Abstract]
Eur J Appl Physiol. 2003 Feb;88(6):535-43. Epub 2002 Dec 14. Long-term exposure to intermittent hypoxia results in increased hemoglobin mass, reduced plasma volume, and elevated erythropoietin plasma levels in man. Heinicke K, Prommer N, Cajigal J, Viola T, Behn C, Schmidt W. [Abstract]
High Alt Med Biol. 2002 Fall;3(3):277-82. Effects of intermittent hypobaric hypoxia on blood lipid concentrations in male coronary heart disease patients. Tin’kov AN, Aksenov VA. [Abstract]
Aviat Space Environ Med 2002 May;73(5):460-5 The effect of low-level normobaric hypoxia on orthostatic responses. Rickards CA, Newman DG. [Abstract]
Acta Pharmacol Sin. 2002 Apr;23(4):305-10 Myocardial capillary angiogenesis and coronary flow in ischemia tolerance rat by adaptation to intermittent high altitude hypoxia.
Zhong N, Zhang Y, Zhu HF, Wang JC, Fang QZ, Zhou ZN. [Abstract]
J Neurosci. 2001 Jul 15;21(14):5381-8 Chronic intermittent hypoxia elicits serotonin-dependent plasticity in the central neural control of breathing. Ling L, Fuller DD, Bach KB, Kinkead R, Olson EB Jr, Mitchell GS.[Abstract]
Am J Physiol Heart Circ Physiol. 2001 Jul;281(1):H132-8. Intermittent hypoxia modulates nNOS expression and heart rate response to sympathetic nerve stimulation. Mohan RM, Golding S, Paterson DJ. [Abstract]
Acta Physiol Scand. 2001 Jun;172(2):89-95 Intermittent hypoxia improves atrial tolerance to subsequent anoxia and reduces stress protein expression. Mohan RM, Golding S, Paterson DJ. [Abstract]
J Appl Physiol. 2001 Apr;90(4):1593-9. Review. Invited review: Physiological and pathophysiological responses to intermittent hypoxia.Neubauer JA.
[Abstract]
FASEB J 2001 Mar 28 Induction of HIF-1a in response to hypoxia is instantaneous.
Jewell UR, Kvietikova I, Scheid A, Bauer C, Wenger RH, Gassmann M. [Abstract]
Pflugers Arch 2001 Mar;441(6):840-3 Very mild exposure to hypoxia for 8 h can induce ventilatory acclimatization in humans. Fatemian M, Kim DY, Poulin MJ, Robbins PA.
[Abstract]
Endocrinology 2001 Feb;142(2):959-962 Hypoxia induces vascular endothelial growth factor gene transcription in human osteoblast-like cells through the hypoxia-inducible factor-2alpha. Akeno N, Czyzyk-Krzeska MF, Gross TS, Clemens TL.[Abstract]
J Appl Physiol 2001 Jan;90(1):17-22 Alterations in enzymes involved in fat metabolism after acute and chronic altitude exposure. Kennedy SL, Stanley WC, Panchal AR, Mazzeo RS.
[Abstract]
Respir Physiol 2000 Oct;123(1-2):39-49 Effects of intermittent hypoxia on the isocapnic hypoxic ventilatory response and erythropoiesis in humans. Garcia N, Hopkins SR, Powell FL. [Abstract]
Pathophysiology 2000 Sep;7(3):165-169 alpha2-Adrenergic-receptor response in reversible increase in hemoglobin concentration in intermittent hypoxia. Kuwahira I I, Kamiya U, Iwamoto T, Ishii M, Moue Y, Ohta Y, Gonzalez NC. [Abstract]
Med Sci Sports Exerc 2000 Apr;32(4):800-804 EPO, red cells, and serum transferrin receptor in continuous and intermittent hypoxia.Koistinen PO, Rusko H, Irjala K, Rajamaki A, Penttinen K, Sarparanta VP, Karpakka J, Leppaluoto J.
[Abstract]
Sheng Li Xue Bao 2000 Apr 25;52(2):89-92 Antiarrhythmic and antioxidative effects of intermittent hypoxia exposure on rat myocardium
[Article in Chinese] Zhang Y, Zhong N, Zhu HF, Zhou ZN. [Abstract]
Aviakosm Ekolog Med 2000;34(2):39-43 The build-up of human reserve potential by exposure to intermittent normobaric hypoxia. [Article in Russian] Berezovskii VA, Levashov MI. [Abstract]
Acta Pharmacol Sin 2000 May;21(5):467-72.Intermittent hypoxia exposure-induced heat-shock protein 70 expression increases resistance of rat heart to ischemic injury.
Zhong N, Zhang Y, Fang QZ, Zhou ZN. [Abstract]
Aviat Space Environ Med 2000 Feb;71(2):125-30. Intermittent hypobaric hypoxia induces altitude acclimation and improves the lactate threshold. Casas M, Casas H, Pages T, Rama R, Ricart A, Ventura JL, Ibanez J, Rodriguez FA, Viscor G. [Abstract]
Biull Eksp Biol Med 1988 Nov;106(11):528-9. [Effect of adaptation to hypoxia on the antioxidant enzyme activity in the liver in animals that have undergone stress].
[Article in Russian] Tverdokhlib VP, Konovalova GG, Lankin VZ, Meerson FZ [Abstract]
Aviat Space Environ Med 1977 Apr;48(4):362-5. Protective effect of hypoxia on oxygen toxicity: possible mechanisms. Brashear RE, Christian JC, Kang KW, Rohn RJ [Abstract]
J Appl Physiol 1970 Apr;28(4):474-81. Protection by altitude acclimatization against lung damage from exposure to oxygen at 825 mm Hg.Brauer RW, Parrish DE, Way RO, Pratt PC, Pessotti RL
High Alt Med Biol. 2005 Spring;6(1):50-9. Effect of a repeated series of intermittent hypoxic exposures on ventilatory response in humans.Katayama K, Fujita H, Sato K, Ishida K, Iwasaki K, Miyamura M. [Abstract]
Biol Chem. 2004 Mar-Apr;385(3-4):217-21. Oxidative stress in the systemic and cellular responses to intermittent hypoxia. Prabhakar NR, Kumar GK. [Abstract]
Respir Physiol Neurobiol. 2004 Apr 20;140(1):1-8. Persistent respiratory changes following intermittent hypoxic stimulation in cats and human beings. Morris KF, Gozal D.
[Abstract]
Space Med Med Eng (Beijing). 2004 Oct;17(5):334-9. [Effects of intermittent normobaric hypoxia training on heart rate variability] Xu X, Lu LL, Chen ZH, Liu XX, Li YZ. [Abstract]
Intermittent high altitude hypoxia protects the heart against lethal Ca2+ overload injury.
Xie Y, Zhu WZ, Zhu Y, Chen L, Zhou ZN, Yang HT. [Abstract]
Int J Cardiol. 2004 Aug;96(2):247-54. Intermittent hypoxia increases exercise tolerance in elderly men with and without coronary artery disease. Burtscher M, Pachinger O, Ehrenbourg I, Mitterbauer G, Faulhaber M, Puhringer R, Tkatchouk E. [Abstract]
Ukr Biokhim Zh. 2003 Nov-Dec;75(6):123-8. [NO-dependent effects during adaptation of rats to intermittent hypoxia] Kurhaliuk NM, Kotsiuruba AV, Bukhanevych OM, Kosiakova HV. [Abstract]
Intermittent hypoxia increases exercise tolerance in elderly men with and without coronary artery disease. Burtscher M, Pachinger O, Ehrenbourg I, Mitterbauer G, Faulhaber M, Puhringer R, Tkatchouk E. Int J Cardiol. 2004 Aug;96(2):247-54.
[Abstract]
J Cereb Blood Flow Metab 1984 Dec;4(4):615-24. Effect of prolonged and intermittent hypoxia on some cerebral enzymatic activities related to energy transduction.
Dagani F, Marzatico F, Curti D, Zanada F, Benzi G [Abstract]
J Appl Physiol 1989 Apr;66(4):1785-8. Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia. Eckardt KU, Boutellier U, Kurtz A, Schopen M, Koller EA, Bauer C [Abstract]
Int J Sports Med 1990 Feb;11 Suppl 1:S15-20. Oxygen transport system before and after exposure to chronic hypoxia. Ferretti G, Boutellier U, Pendergast DR, Moia C, Minetti AE, Howald H, di Prampero PE [Abstract]
Diabetes 1998 Sep;47(9):1480-8. Hypoxia upregulates glucose transport activity through an adenosine-mediated increase of GLUT1 expression in retinal capillary endothelial cells.
Takagi H, King GL, Aiello LP [Abstract]
Biull Eksp Biol Med 1995 Dec;120(12):565-7 [Hypoxic training stimulates the insulin apparatus of the pancreas in intact and diabetic rats].[Article in Russian]
Kolesnik IuM, Serdenko MM, Abramov AV
Dokl Akad Nauk SSSR 1990;311(3):756-8 [Sympathetic nerves control the process of microvascular neogenesis induced by adaptation to hypoxia]. [Article in Russian]
Koshelev VB, Kondashevskaia MV, Rodionov IM
Vestn Ross Akad Med Nauk 1997;(5):46-50 [Adaptation to hypoxia as a factor enhancing work capacity]. [Article in Russian] Kozlov SA [Abstract]
Int J Biometeorol 1977 Jun;21(2):93-122. Effects of high altitude stay on the incidence of common diseases in man. Singh I, Chohan IS, Lal M, Khanna PK, Srivastava MC, Nanda RB, Lamba JS, Malhotra MS
J Appl Physiol 1990 Jun;68(6):2369-72. Is hypoxia a stimulus for synthesis of oxidative enzymes and myoglobin? Terrados N, Jansson E, Sylven C, Kaijser L [Abstract]
